Using data to drive breakthroughs in eye cancer research
Date published:
14 October 2025
Dr. Antonio Eleuteri, consultant statistics specialist at University Hospitals of Liverpool Group (UHLG), plays a key role in the Research and Innovation team. Since joining the Medical Physics and Clinical Engineering Department in 2006, he has made significant contributions to clinical research by through the application of statistical analysis methods and the creation of new analysis techniques.
His expertise were recently highlighted in two publications on choroidal and uveal melanoma, two types of eye cancer, where he provided critical statistical support using real-world data.
In one paper, it was determined that Ruthenium-106 brachytherapy (a type of radiation treatment) is a good option for treating small eye tumours (choroidal melanomas). However, larger tumours may need different treatments, or sometimes even surgery to remove the eye. The study also suggested using a treatment to shrink the tumour first, before applying brachytherapy. This approach helps preserve vision and lowers the chances of the cancer spreading.
Another study challenged the assumption that small uveal melanomas are low-risk, showing they can carry aggressive genetic traits requiring closer monitoring and early intervention.
Dr Eleuteri said: "The two most recent publications are a strong reflection of the research I’ve contributed to, showcasing the clinical knowledge gained from data by using statistical analysis.
“I’ve collaborated with clinicians and scientists not only at UHLG but across the globe, exploring innovative ways to use data to improve treatments for and understanding conditions such as choroidal and uveal melanoma.
“Since starting my career at UHLG, I’ve consistently supported research initiatives, applying my background in Theoretical Computer Science and my PhD in Mathematics and Statistics to tackle real-world challenges, ultimately enhancing patient care."
Prior to working in health, Dr. Eleuteri has contributed to the high-profile LIGO/Virgo collaboration, an international effort to detect and study gravitational waves from events like black hole or neutron star collisions. This ground-breaking work, which earned the 2017 Nobel Prize in Physics, continues to influence his research today.
Beyond data analysis, Dr. Eleuteri ensures research conclusions are robust and clinically relevant, enabling tailored and evidence-based treatments. His work shows the vital role of statisticians in translating research into improved patient care.
Dr. Eleuteri provides support to Research and Innovation staff including study design, power analysis, analysis of observational and trial data, validation of predictive models, software implementation of numerical algorithms.
For more information on the Innovation team at UHLG, click here.
To read the latest articles Dr Eleuteri has been part of click the links below:
If you are a staff member and want to discuss any support from Antonio, please email innovation@liverpoolft.nhs.uk
References
These studies were carried out in collaboration with Liverpool-based colleagues, including Prof. Heinrich Heimann, Prof. Rumana N. Hussain (UHLG), and Prof. Sarah E. Coupland (University of Liverpool), among others.
