The University Hospital of Liverpool Group are UHLG dedicated to advancing patient care through cutting-edge research in anaesthesia.

Our ongoing clinical trials explore new treatments and techniques to improve safety, recovery, and outcomes for patients undergoing surgery. Explore our current studies and learn how we’re working to shape the future of anaesthetic care

The CRASH-4 trial will test if giving a shot of tranexamic acid into the muscle right after a mild head injury in older adults can stop bleeding in the brain before it even starts and help recovery.

The main goal of the trial is to find out the best time for people to start or restart a blood-thinning medicine called a DOAC after a head injury.

he study will also look at how well people recover, their overall quality of life, how many people pass away, the costs of treatment, and what people and their caregivers think about starting or restarting the medicine.

To study comparing two medicines that help stop lung problems and help patients recover better after major surgery with general anaesthesia.

To find out if using a special breathing tube, a supraglottic airway, works better than the usual tube (tracheal intubation) for adults who have a cardiac arrest in the hospital.

To see if giving anesthesia only through the veins (called TIVA) can lower problems after surgery—like heart injury or infections—by keeping blood sugar from getting too high during major surgeries that don’t involve the heart. The study will also try to find out who is more likely to have high blood sugar during surgery.

This study will see if adding a pain relief method called RSCs to regular patient-controlled pain medicine helps people feel less pain, have fewer side effects, and be more satisfied after emergency stomach surgery.

The RADICAL study will involve 250 patients from 20 UK clinics, randomly receiving real or placebo treatment. Over two years, researchers will track pain, function, health, wellbeing, and cost-effectiveness to see if the treatment works.

Long-term lower back pain affects 10–15% of adults and impacts daily life and mood.r.

A large study at multiple sites, testing several treatments openly, with a built-in initial trial and an ongoing cost analysis.