Hormone Therapy for Premature Ovarian Insufficiency (POI): Randomised Trial and Long-Term Evaluation
When menopause occurs in women under the age of 40 it is called Premature Ovarian Insufficiency (POI). Those with POI can experience unpleasant menopausal symptoms, and in the long-term can be at higher risk of bone thinning, fractures, heart disease and memory problems compared with women who experience menopause at a later, more typical age. Treatments can involve hormone replacement therapy (HRT) and the combined contraceptive pill (COC) - both have advantages and disadvantages, and this research is to determine which is best for relief of symptoms and for long-term risks using questionnaires and bone density measurements, as well as blood samples.
If you are over 18 and under 40 and have a diagnosis of POI, you could be eligible for this trial.
Reduction of Surgical Site Infection using several Novel Interventions
When undergoing surgery, there is a risk of developing a surgical site infection (SSI). ROSSINI2 is investigating whether different in-theatre interventions reduce the rate of SSIs in abdominal surgery (excluding c-sections). If you choose to take part, you will be randomly allocated an intervention, or you may be in the control group in which you will undergo your operation in the normal way with no trial intervention used.
If you are interested, please contact the research team at research@lwh.nhs.uk or via phone at 0151 702 4496, where they will provide information about the trial prior to surgery. You can also discuss this with your surgeon.
Sugammadex for preventIoN oF pOst-operative pulmoNary complIcAtions (SINFONIA)
This study is looking into how best to look after patients who are having surgery and undergoing general anaesthetic. As part of general anaesthetic you are given a drug to relax your muscles, and at the end of surgery you are given a drug to reverse the effects of the muscle relaxant.
This trial is comparing two different drug treatments, both of which are commonly used to reverse muscle relaxants. These are sugammadex of neostigmine with co-administration of glycopyrrolate. The study aims to show if one drug is better than the other, particularly in reducing the risk of breathing problems and pneumonia.
If you are interested in taking part or learning more information about the study, please call 0151 702 4346 or email research@lwh.nhs.uk.
Proactive against reactive therapy for the prevention of lichen sclerosus exacerbation and progression of disease – a pragmatic, parallel group randomised controlled trial with embedded economic evaluation and process evaluation
The aim of the study is to assess whether in people 5 years and older with controlled vulval Lichen Sclerosis, if proactive therapy is better than reactive therapy in reducing the number of flares. If you take part in the study you will be randomised to either reactive treatment (using prescribed steroid creams when you have a flare) or proactive treatment (using prescribed steroid creams continuously) to see which one is better in the short and long term.
If you are interested in taking part, please contact the research nurses on 0151 702 4496, or research@lwh.nhs.uk
HYPATIA - A prospective randomised controlled trial of Hydroxychloroquine to improve Pregnancy Outcome in women with Antiphospholipid Antibodies
If you have antiphospholipid antibodies or antiphospholipid syndrome and you are currently planning for pregnancy, you may be eligible for the HYPATIA study. We are looking to answer the question as to whether hydroxychloroquine may help improve pregnancies in women with antiphospholipid antibodies.
If you are interested in taking part, please contact the research team at research@lwh.nhs.uk, or call 0151 702 4496.
Evaluating a new patient-reported outcome questionnaire to assess the outcomes of prolapse, incontinence and mesh complication surgery as part of the APPRAISE Study
If you have undergone pelvic floor surgery for either pelvic organ prolapse, urinary incontinence and/or mesh complications, you may be eligible to take part in the APPRAISE study, a questionnaire study aiming to explore your experiences of pelvic floor surgery and the impact this has had on your quality of life and the symptoms you have experienced.
This aims to create a final version of a questionnaire that could then be used to improve the care of people undergoing pelvic floor surgery in the future, and inform and support healthcare professionals and policy makers.
If you would like to take part, please contact the research team at research@lwh.nhs.uk, or call us on 0151 702 4496.